@article {Foster59, author = {P M Foster and M W Cook and L V Thomas and D G Walters and S D Gangolli}, title = {Differences in urinary metabolic profile from di-n-butyl phthalate-treated rats and hamsters. A possible explanation for species differences in susceptibility to testicular atrophy.}, volume = {11}, number = {1}, pages = {59--61}, year = {1983}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {A high-performance liquid chromatographic method for the direct analysis of the urinary metabolites of di-n-butyl phthalate (DBP) is described. In both rats and hamsters the major urinary metabolite found after treatment with either DBP or mono-n-butyl phthalate (MBP) was MBP glucuronide and not MBP as previously reported. The levels of unconjugated MBP in the urine of animals treated with DBP or MBP were three- to fourfold higher in the rat than in the hamster. However, intestinal esterase activities were comparable in the two species, whereas the activities of testicular beta-glucuronidase were significantly higher in rats compared to hamsters. It is possible that the differences in the concentration of free MBP, a substance known to produce testicular damage directly in the rat in vitro, may account for the lack of injury seen in hamsters after oral treatment with either DBP or MBP.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/11/1/59}, eprint = {https://dmd.aspetjournals.org/content/11/1/59.full.pdf}, journal = {Drug Metabolism and Disposition} }