PT  - JOURNAL ARTICLE
AU  - K. D. LANCLOS
AU  - EDWARD BRESNICK
TI  - INITIATION FACTOR ACTIVITY IN LIVER AFTER 3-METHYLCHOLANTHRENE ADMINISTRATION
DP  - 1973 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 239--247
VI  - 1
IP  - 1
4099  - http://dmd.aspetjournals.org/content/1/1/239.short
4100  - http://dmd.aspetjournals.org/content/1/1/239.full
SO  - Drug Metab Dispos1973 Jan 01; 1
AB  - A liver polyribosomal extract was prepared by high-salt treatment from 3-MC- or BNF-treated rats and was compared with a similarly prepared extract from control liver with respect to the ability to stimulate poly U-directed 14C-phenylalanine incorporation in a cell-free system from liver. The results demonstrated a several-fold stimulation by both extracts from 3-MC- and BNF-treated animals. It was shown that neither amino acid activation nor elongation was affected by such treatment. The ribosomal high-salt extract was separated into M1 and M3 + M2 fractions. The stimulatory effect was associated with the latter. Implications of a possible role of these high-salt factors in enzyme induction are discussed. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics