PT  - JOURNAL ARTICLE
AU  - Lehman, J P
AU  - Fenselau, C
AU  - Depaulo, J R
TI  - Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine.
DP  - 1983 May 01
TA  - Drug Metabolism and Disposition
PG  - 221--225
VI  - 11
IP  - 3
4099  - http://dmd.aspetjournals.org/content/11/3/221.short
4100  - http://dmd.aspetjournals.org/content/11/3/221.full
SO  - Drug Metab Dispos1983 May 01; 11
AB  - The quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine were shown to be conjugated in vitro using an immobilized rabbit hepatic microsomal enzyme preparation. It was shown that fast atom bombardment mass spectrometry could be used for direct characterization of these involatile, thermally labile metabolites. The quaternary ammonium-linked glucuronides of amitriptyline and imipramine were demonstrated to be present in urine from patients receiving therapeutic doses of these tricyclic antidepressants.