RT Journal Article
SR Electronic
T1 Quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 221
OP 225
VO 11
IS 3
A1 J P Lehman
A1 C Fenselau
A1 J R Depaulo
YR 1983
UL http://dmd.aspetjournals.org/content/11/3/221.abstract
AB The quaternary ammonium-linked glucuronides of amitriptyline, imipramine, and chlorpromazine were shown to be conjugated in vitro using an immobilized rabbit hepatic microsomal enzyme preparation. It was shown that fast atom bombardment mass spectrometry could be used for direct characterization of these involatile, thermally labile metabolites. The quaternary ammonium-linked glucuronides of amitriptyline and imipramine were demonstrated to be present in urine from patients receiving therapeutic doses of these tricyclic antidepressants.