PT  - JOURNAL ARTICLE
AU  - Hooper, W D
AU  - Treston, A M
AU  - Jacobsen, N W
AU  - Dickinson, R G
AU  - Eadie, M J
TI  - Identification of p-hydroxyprimidone as a minor metabolite of primidone in rat and man.
DP  - 1983 Nov 01
TA  - Drug Metabolism and Disposition
PG  - 607--610
VI  - 11
IP  - 6
4099  - http://dmd.aspetjournals.org/content/11/6/607.short
4100  - http://dmd.aspetjournals.org/content/11/6/607.full
SO  - Drug Metab Dispos1983 Nov 01; 11
AB  - Urine specimens from rats and humans who received single doses of primidone (PRM) have been investigated by GC/MS procedures. In addition to the previously documented metabolites of PRM, a small chromatographic peak was encountered which had a mass spectrum suggesting a hydroxy-PRM derivative. Synthesis of p-hydroxy-PRM from PRM was effected; the para isomer was separated from unwanted isomers by preparative HPLC. The PMR spectrum of the synthetic compound proved the position of the hydroxy substituent to be para. This compound had identical GC retention time and an almost identical mass spectrum with that obtained in the urinary extracts. Para-hydroxy-PRM was therefore confirmed as a new, minor metabolite of PRM in rat and man.