PT  - JOURNAL ARTICLE
AU  - R B van Breemen
AU  - C Fenselau
TI  - Acylation of albumin by 1-O-acyl glucuronides.
DP  - 1985 May 01
TA  - Drug Metabolism and Disposition
PG  - 318--320
VI  - 13
IP  - 3
4099  - http://dmd.aspetjournals.org/content/13/3/318.short
4100  - http://dmd.aspetjournals.org/content/13/3/318.full
SO  - Drug Metab Dispos1985 May 01; 13
AB  - Representative examples of drug metabolites containing a carboxylic acid group conjugated to glucuronic acid are shown to be active chemical electrophiles, which acylate albumin in vitro through transesterification reactions. Based on these and other observations, we propose that this acylating reactivity is characteristic of 1-O-acyl glucuronides as a class, and that albumin is representative of many susceptible biopolymers. The hypothesis is advanced that this reaction can occur in vivo as well, and that it may offer a molecular mechanism for the physiological activity or toxicity of some xenobiotic and lipophilic compounds.