@article {Taylor459, author = {G Taylor and B J Marafino, Jr and J A Moore and V Gurley and T F Blaschke}, title = {Interferon reduces hepatic drug metabolism in vivo in mice.}, volume = {13}, number = {4}, pages = {459--463}, year = {1985}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The effects of two highly purified human leukocyte interferons (IFN-A and IFN-AD) on drug-metabolizing capacity in mice have been investigated. IFN-AD was found to produce significant changes in antipyrine half-life, assessed by analysis of 14CO2 exhalation rates following 14C-antipyrine administration. By contrast, IFN-A, which has considerably less antiviral potency than IFN-AD, was found to have no effect on antipyrine half-life. The administration regimen was found to markedly alter the effects seen with IFN-AD. When IFN-AD was given as single daily doses (5 X 10(7) units/kg/day X 3 days), the half-life of antipyrine increased by a mean of 40\% (from 21.0 to 28.9 min). However, when a smaller daily dose (3 X 10(7) units/kg/day) was given as a continuous infusion, the antipyrine half-life increased by more than 3-fold (from 20.8 to 68.5 min) after 3 days of administration. Continued infusion for a further 3 days produced no additional change in antipyrine half-life. These results demonstrate that human leukocyte interferons can significantly inhibit hepatic metabolic activity in vivo.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/13/4/459}, eprint = {https://dmd.aspetjournals.org/content/13/4/459.full.pdf}, journal = {Drug Metabolism and Disposition} }