TY - JOUR T1 - ABSORPTION, DISTRIBUTION, AND EXCRETION OF QUINGESTANOL ACETATE BY THE RAT JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 530 LP - 536 VL - 1 IS - 2 AU - FRANCIS R. ZULESKI AU - DALE DIANE LEWIS AU - FREDERICK J. DI CARLO Y1 - 1973/03/01 UR - http://dmd.aspetjournals.org/content/1/2/530.abstract N2 - Tritium- and 14C-labeled preparations were employed to learn the fate of quingestanol acetate after oral administration to female and male rats. Drug absorption occurred quickly with evidence of some cleavage of the cyclopentyl ether substituent from the steroid nucleus; peak steroid levels were observed 1 hr after treatment; lower levels were detectable for 6 days. Male rats excreted more drug steroid (23.6% of the dose) in the urine in 6 days than did females (16.0%). Examination of the urine provided clear evidence that the cyclopentyl enol ether was at least partially removed, and this point was substantiated by the exhalation of 24.5% of 14C1 cyclopentyl carbon as 14CO2. The urine contained low levels of unconjugated and glucuronide metabolites; most of the drug was excreted as sulfates and unidentified polar compounds. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics ER -