PT  - JOURNAL ARTICLE
AU  - DENNIS E. DRAYER
AU  - MARCUS M. REIDENBERG
TI  - METABOLISM OF TETRALIN AND TOXICITY OF CUPREX IN MAN
DP  - 1973 May 01
TA  - Drug Metabolism and Disposition
PG  - 577--579
VI  - 1
IP  - 3
4099  - http://dmd.aspetjournals.org/content/1/3/577.short
4100  - http://dmd.aspetjournals.org/content/1/3/577.full
SO  - Drug Metab Dispos1973 May 01; 1
AB  - A patient ingested about 250 ml of Cuprex, an ectoparasiticide containing tetralin (1,2,3, 4-tetrahydronaphthalene). copper oleate, paraffin oil, and acetone, in an episode of self-poisoning. This caused a mild degree of liver and kidney damage that subsided within two weeks. The main urinary metabolite of tetralin was 1,2,3,4-tetrahydro-1-naphthol. The glucuronides of this naphthol and of 1,2,3,4-tetrahydro-2-naphthol were also detected in the urine. Hydroxylation of tetralin only on the alicyclic ring and mainly at the benzylic carbon suggests that tetralin metabolism may occur via a pathway involving the formation of free radicals. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics