RT Journal Article
SR Electronic
T1 N-dephenylation of CERM 3517 (mociprazine) in beagle dogs. A mass spectrometric determination.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 147
OP 154
VO 14
IS 2
A1 J F Pognat
A1 A Enreille
A1 J L Chabard
A1 N Busch
A1 J A Berger
YR 1986
UL http://dmd.aspetjournals.org/content/14/2/147.abstract
AB CERM 3517 (mociprazine), a new antiemetic compound, was administered orally at 10 mg/kg twice a day for 4 days to six Beagle dogs in order to identify the major metabolite. Mass spectrometric comparison of this metabolite and a synthesized reference compound (CERM 4082) showed that both had identical structures. The metabolite originated from cleavage of the aromatic moiety. After iv administration of CERM 3517 (0.9 mg/kg) and CERM 4082 (0.6 mg/kg) to five beagle dogs, 13% and 56% of the dose, respectively, were eliminated in the urine as CERM 4082 compound. It can be calculated that at least 25% of CERM 3517 was biotransformed by N-dephenylation.