TY - JOUR T1 - Identification of trimoprostil metabolites excreted in rat bile formed by oxidation and taurine conjugation. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 465 LP - 470 VL - 14 IS - 4 AU - S J Kolis AU - E J Postma AU - T H Williams AU - G J Sasso Y1 - 1986/07/01 UR - http://dmd.aspetjournals.org/content/14/4/465.abstract N2 - 14C-Trimoprostil was administered iv and orally to male rats. Radioactivity was excreted mainly via the feces after both routes of drug administration. Bile duct-cannulated rats excreted an average of 76% of an iv dose in the bile within 6 hr after dosing. Four biliary metabolites were isolated by HPLC and identified by proton NMR spectroscopy and mass spectrometry. These metabolites were taurine conjugates of: trimoprostil (approximately 11% of dose), 5,6-dihydro-2,3-dinor trimoprostil (approximately 5% of dose), 3,4-dehydro trimoprostil (less than 5% of dose) and 5,6-dihydro-2,3,4,5-tetranor trimoprostil (less than 5% of dose). ER -