RT Journal Article
SR Electronic
T1 Identification of trimoprostil metabolites excreted in rat bile formed by oxidation and taurine conjugation.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 465
OP 470
VO 14
IS 4
A1 S J Kolis
A1 E J Postma
A1 T H Williams
A1 G J Sasso
YR 1986
UL http://dmd.aspetjournals.org/content/14/4/465.abstract
AB 14C-Trimoprostil was administered iv and orally to male rats. Radioactivity was excreted mainly via the feces after both routes of drug administration. Bile duct-cannulated rats excreted an average of 76% of an iv dose in the bile within 6 hr after dosing. Four biliary metabolites were isolated by HPLC and identified by proton NMR spectroscopy and mass spectrometry. These metabolites were taurine conjugates of: trimoprostil (approximately 11% of dose), 5,6-dihydro-2,3-dinor trimoprostil (approximately 5% of dose), 3,4-dehydro trimoprostil (less than 5% of dose) and 5,6-dihydro-2,3,4,5-tetranor trimoprostil (less than 5% of dose).