RT Journal Article SR Electronic T1 Synthesis, characterization, and quantitation of para-hydroxymethadone, a metabolite of methadone in the rat. JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 477 OP 481 VO 14 IS 4 A1 B M Gerardy A1 D Kapusta A1 P Dumont A1 J H Poupaert YR 1986 UL http://dmd.aspetjournals.org/content/14/4/477.abstract AB To demonstrate a p-hydroxylation process in the metabolism of methadone, we have synthesized para-hydroxymethadone and characterized it by spectroscopy (IR, 13C-NMR, mass spectrometry) and chromatography (thin layer chromatography, gas-liquid chromatography, and HPLC). para-Hydroxymethadone was isolated by HPLC from the urine of rats treated with (R,S)-methadone. para-Hydroxymethadone in the urine and in the bile represents 1.82 and 38.08%, respectively, of the administered dose. para-Hydroxymethadone does not exhibit any opioid-like activity.