RT Journal Article
SR Electronic
T1 Disposition of radiolabeled flumequine in rat and dog.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 555
OP 558
VO 14
IS 5
A1 L I Harrison
A1 D Schuppan
A1 S R Rohlfing
A1 A R Hansen
A1 J F Gerster
A1 C S Hansen
A1 M L Funk
A1 R E Ober
YR 1986
UL http://dmd.aspetjournals.org/content/14/5/555.abstract
AB Single doses of 14C-flumequine (a urinary tract antibacterial) were given to rats and dogs. Unchanged drug accounted for more than 80% of the drug in plasma of rats but only 25-50% in plasma of dogs. Although only a small percentage of the dose was excreted in the urine of each species as unchanged drug, a wide differentiation in the urinary metabolite profiles was observed. No significant tissue retention was seen in rats or dogs.