RT Journal Article
SR Electronic
T1 METABOLIC DISPOSITION OF THIAMINE TETRAHYDROFURFURYL DISULFIDE IN DOG AND MAN
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 698
OP 703
VO 1
IS 5
A1 CHOZO MITOMA
YR 1973
UL http://dmd.aspetjournals.org/content/1/5/698.abstract
AB The absorption and tissue distribution of two forms of thiamine tetrahydrofurfuryl disulfide (TTFD)—free base and HCl salt—were compared in dogs. The peak blood level of the thiamine moiety and the time at which that level was attained were similar after oral administration of both forms of TTFD. Also, there was no appreciable difference between the two forms in the tissue distribution patterns of thiamine and 35S-label in the tetrahydrofurfurylmercaptan moiety. The absorption of the tetrahydrofurfurylmercaptan moiety was nearly quantitative, and it was excreted predominantly in the urine after oral or iv administration of TTFD. The excretion of thiamine, however, was approximately equally divided between the urine and feces after oral intake of TTFD and almost exclusively in the urine after iv administration. These facts indicate the limited intestinal absorption of the thiamine moiety in contrast to the 35S-label in the tetrahydrofurfurylmercaptan moiety of TTFD. After oral intake of TTFD by man (4 mg/kg, average) and dog (3 mg/kg), the percentage of thiamine excreted in the urine after 72 hours was similar but the maximum blood level of thiamine attained was considerably higher in man than in the dog. Copyright © 1973 by The American Society for Pharmacology and Experimental Therapeutics