RT Journal Article
SR Electronic
T1 Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 218
OP 220
VO 17
IS 2
A1 A Wahlström
A1 K Persson
A1 A Rane
YR 1989
UL http://dmd.aspetjournals.org/content/17/2/218.abstract
AB Metabolic interaction between naloxone and morphine has been studied in vitro in human liver microsomes. Morphine and naloxone are metabolized by an UDP-glucuronyl transferase to their 3-glucuronides. There is a very good correlation between the rates of formation of morphine-3-glucuronide and of naloxone-3-glucuronide. Naloxone seems to have a 10-fold higher affinity for the enzyme binding site than does morphine. Morphine and naloxone show bisubstrate kinetic patterns which appear very similar.