TY - JOUR T1 - An active, aldehydic metabolite of the cell-differentiating agent hexamethylene bisacetamide. JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 398 LP - 401 VL - 17 IS - 4 AU - B Subramanyam AU - P S Callery AU - M J Egorin AU - S W Snyder AU - B A Conley Y1 - 1989/07/01 UR - http://dmd.aspetjournals.org/content/17/4/398.abstract N2 - 6-Acetamidohexanal has been identified in human plasma and urine as a metabolite of the cell-differentiating agent, hexamethylene bisacetamide (HMBA). Synthesis of 6-acetamidohexanal was accomplished by oxidation of 6-acetamido-1-hexanol with pyridinium dichromate. A screen of 6-acetamidohexanal for cell-differentiating activity in HL60 human leukemia cells revealed a higher level of activity than HMBA or N-acetyl-1,6-diaminohexane, another active metabolite of HMBA. The results are consistent with a pathway which involves deacetylation of HMBA, oxidative deamination of the resulting N-acetyl-1,6-diaminohexane to yield 6-acetamidohexanal, and further oxidation to give 6-acetamidohexanoic acid. ER -