PT  - JOURNAL ARTICLE
AU  - W J Waddell
AU  - C Marlowe
AU  - T Yamamoto
AU  - M J Clark
TI  - Inhibition of the metabolism of urethane in the mouse by dimethyl sulfoxide (DMSO).
DP  - 1989 Sep 01
TA  - Drug Metabolism and Disposition
PG  - 469--472
VI  - 17
IP  - 5
4099  - http://dmd.aspetjournals.org/content/17/5/469.short
4100  - http://dmd.aspetjournals.org/content/17/5/469.full
SO  - Drug Metab Dispos1989 Sep 01; 17
AB  - Previous studies from this laboratory have shown that alcohols inhibit the localization of nitrosonornicotine and urethane in tissues of the mouse. Subsequent studies demonstrated that this inhibition of the localization of urethane was apparently due to an almost total inhibition of the metabolism of that compound by ethanol. We now report that dimethyl sulfoxide (DMSO) also almost completely inhibits the localization of urethane metabolites in tissues of the mouse and maintains a high concentration of urethane in blood. Since metabolism is essentially the only route of elimination of urethane in the mouse, this indicates that DMSO inhibits the metabolism of urethane. These studies lend further support to the suggestion that urethane is metabolized by either an alcohol dehydrogenase, an aldehyde dehydrogenase, or an alcohol-preferring isozyme of cytochrome P-450. These results indicate that studies on the metabolism as well as the carcinogenic activity of urethane (and possibly other chemicals) also may be affected by concurrent administration of DMSO.