PT  - JOURNAL ARTICLE
AU  - E Benfenati
AU  - R Fanelli
AU  - E Bosone
AU  - C Biffi
AU  - R Caponi
AU  - M Cianetti
AU  - P Farina
TI  - Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent.
DP  - 1991 Sep 01
TA  - Drug Metabolism and Disposition
PG  - 913--916
VI  - 19
IP  - 5
4099  - http://dmd.aspetjournals.org/content/19/5/913.short
4100  - http://dmd.aspetjournals.org/content/19/5/913.full
SO  - Drug Metab Dispos1991 Sep 01; 19
AB  - The compound IBI-P-01028, or R,S-cis-6-(6'-carboxyhexyl)-7-trans-n-hexyl-1,3-diazaspiro-[4-4]-nona n-2,4- dione, is a new cytoprotective agent under development. To study the metabolites of this compound in laboratory animals, we administered it to dogs and rats, and analyzed extracts from dog and rat urine, and from dog plasma, by GC-MS. The metabolic profiles were different in the rat and dog. In the dog (plasma and urine), one metabolite was found, and in the rat urine two other metabolites were found. The unmetabolized drug was found only in the dog plasma and urine.