@article {Stehly70, author = {G R Stehly and S M Plakas}, title = {Disposition of 1-naphthol in the channel catfish (Ictalurus punctatus).}, volume = {20}, number = {1}, pages = {70--73}, year = {1992}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The pharmacokinetics, tissue distribution, and metabolism of 1-naphthol were examined in the channel catfish (Ictalurus punctatus). Catfish were administered [1-14C]1-naphthol intravascularly at 1, 5, or 25 mg/kg or orally at 1 mg/kg. Plasma data for 1-naphthol were fitted by a three-compartment pharmacokinetic model. There were dose-related changes in the area under the plasma concentration vs. time curve, apparent volume of distribution, and total body clearance after intravascular dosing. After oral dosing, peak plasma concentrations of 1-naphthol occurred at 1 hr; parent compound made up less than 15\% of the total radioactivity, and the bioavailability was 32\%. Plasma protein binding was 92\% and was independent of concentration. 1-Naphthol and metabolites were rapidly eliminated from the tissues after oral dosing; less than 1\% of the administered dose remained at 24 hr. Renal excretion was the primary route of elimination of total 14C. Approximately 60\% of the oral dose was excreted in the urine within 48 hr. Parent 1-naphthol made up 1\% of the urinary 14C. Major metabolites in the urine were sulfate and glucuronide conjugates, which composed 65 and 28\% of the total 14C, respectively. Biliary excretion accounted for 7\% of the oral dose. The glucuronide conjugate and an unidentified polar metabolite made up the majority of the biliary 14C. The high capacity of channel catfish for conjugative metabolism of 1-naphthol was demonstrated. The dose dependency of pharmacokinetic values could not be explained by saturable metabolism or plasma protein binding.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/20/1/70}, eprint = {https://dmd.aspetjournals.org/content/20/1/70.full.pdf}, journal = {Drug Metabolism and Disposition} }