PT  - JOURNAL ARTICLE
AU  - G P Meier
AU  - S B Park
AU  - G C Yee
AU  - D J Gmur
TI  - Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17.
DP  - 1990 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 68--71
VI  - 18
IP  - 1
4099  - http://dmd.aspetjournals.org/content/18/1/68.short
4100  - http://dmd.aspetjournals.org/content/18/1/68.full
SO  - Drug Metab Dispos1990 Jan 01; 18
AB  - A novel metabolite of cyclosporin A was observed in human blood and urine. An analytical sample of this metabolite was isolated from human urine and the structure was determined to be (8-hydroxy-6,7-dihydro-MeBMT1) cyclosporin based on the 1H-NMR, 13C-NMR, FAB-MS, and HPLC characteristics of the biological sample as well as by comparison with a synthetically derived authentic sample. The significance of this metabolite in terms of the pathway by which cyclosporin A is metabolized is discussed.