PT  - JOURNAL ARTICLE
AU  - ARTHUR K. CHO
AU  - BJÖRN LINDEKE
AU  - CHECK Y. SUM
TI  - THE N-HYDROXYLATION OF PHENTERMINE (2-METHYL-2-AMINO-1-PHENYLPROPANE)
DP  - 1974 Jan 01
TA  - Drug Metabolism and Disposition
PG  - 1--8
VI  - 2
IP  - 1
4099  - http://dmd.aspetjournals.org/content/2/1/1.short
4100  - http://dmd.aspetjournals.org/content/2/1/1.full
SO  - Drug Metab Dispos1974 Jan 01; 2
AB  - A gas chromatographic procedure for the estimation of N-hydroxyphentermine (2-methyl-2-hydroxyamino-1-phenylpropane) has been used to characterize the enzyme system present in liver microsome preparations that effects the N-hydroxylation of phentermine (2-methyl-2-hydroxyamino-1-phenylpropane) in vitro. When rabbit liver microsomes were used, the reaction was inhibited by SKF 525-A and by carbon monoxide. The rabbit microsomal preparation was unstable and decayed to 50% of original activity after 10 days of storage at -70°C. The relative order of N-hydroxylation activity in the three species examined was rabbit > guinea pig ≥ rat. Kinetic studies were also conducted. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics