PT  - JOURNAL ARTICLE
AU  - W Krause
AU  - B Düsterberg
AU  - U Jakobs
AU  - G A Hoyer
TI  - Biotransformation of proterguride in the perfused rat liver.
DP  - 1993 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 203--208
VI  - 21
IP  - 2
4099  - http://dmd.aspetjournals.org/content/21/2/203.short
4100  - http://dmd.aspetjournals.org/content/21/2/203.full
SO  - Drug Metab Dispos1993 Mar 01; 21
AB  - The metabolic pathway of the dopaminagonistic ergoline derivative, proterguride, was studied in vitro in a rat liver perfusion experiment. Metabolites were isolated by preparative HPLC and identified by MS and NMR analyses. In total, seven compounds could be identified. The metabolic steps involved in the biodegradation of proterguride are N-deethylation, N-oxidation, hydroxylation, and/or dehydrogenation and oxidative cleavage of the indole ring.