RT Journal Article
SR Electronic
T1 Biotransformation of proterguride in the perfused rat liver.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 203
OP 208
VO 21
IS 2
A1 W Krause
A1 B Düsterberg
A1 U Jakobs
A1 G A Hoyer
YR 1993
UL http://dmd.aspetjournals.org/content/21/2/203.abstract
AB The metabolic pathway of the dopaminagonistic ergoline derivative, proterguride, was studied in vitro in a rat liver perfusion experiment. Metabolites were isolated by preparative HPLC and identified by MS and NMR analyses. In total, seven compounds could be identified. The metabolic steps involved in the biodegradation of proterguride are N-deethylation, N-oxidation, hydroxylation, and/or dehydrogenation and oxidative cleavage of the indole ring.