TY - JOUR T1 - ISOLATION OF PENTAERYTHRITOL NITRATES AND THEIR GLUCURONIDES JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 40 LP - 45 VL - 2 IS - 1 AU - FRANZ-JOSEF LEINWEBER AU - MYRIAM D. MELGAR AU - MALCOLM C. CREW AU - FREDERICK J. DI CARLO Y1 - 1974/01/01 UR - http://dmd.aspetjournals.org/content/2/1/40.abstract N2 - 14C-Labeled pentaerythritol (PE) mononitrate and dinitrate were isolated from 14C-PE trinitrate hydrolysates by adsorption chromatography on Sephadex. Glucuronides of the mono-, di-, and trinitrates of PE were obtained by applying counter-current distribution techniques to the urine and bile of rats treated with 14C-PE trinitrate. PE glucuronide was not detected in this urine or bile, and could not be biosynthesized from PE either by direct glucuronidation with uridine diphosphate glucuronic acid or by transglucuronidation with phenolphthalein glucuronide. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics ER -