@article {Gordon596, author = {W P Gordon and H Cheng and D L Larsen and J A Ragner and N G Landmesser}, title = {Identification of urinary metabolites of 8-methyl-8-azabicyclo- 3,2,1] octan-3-yl 3,5-dichlorobenzoate (MDL 72,222) in the dog and monkey.}, volume = {20}, number = {4}, pages = {596--602}, year = {1992}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The metabolism of 8-methyl-8-azabicyclo- 3,2,1]octan-3-yl 3,5-dichlorobenzoate (MDL 72,222) was studied in the dog and monkey. Four urinary metabolites were detected by HPLC, HPLC/MS, and GC/MS, and were identified by comparison to authentic standards. The major metabolite in the dog, approximately 41\% of the administered dose excreted between 0 and 120 hr, was the MDL 72,222-N-oxide. On the other hand, the major metabolite in the monkey was the glycine conjugate of 3,5-dichlorobenzoic acid (greater than 56\% of the dose). Seven percent of the dose in the monkey urine was free 3,5-dichlorobenzoic acid. N-Desmethyl MDL 72,222 was present at 2.5 and 1\% in the dog and monkey, respectively. Very little (less than 1\%) of the parent compound was found in urine. The major pathways of metabolism of MDL 72,222 are N-oxidation, N-demethylation, ester hydrolysis, and amino acid conjugation.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/20/4/596}, eprint = {https://dmd.aspetjournals.org/content/20/4/596.full.pdf}, journal = {Drug Metabolism and Disposition} }