@article {Benoit877, author = {E Benoit and T Cresteil and J L Riviere and P Delatour}, title = {Specific and enantioselective sulfoxidation of an aryl-trifluoromethyl sulfide by rat liver cytochromes P-450.}, volume = {20}, number = {6}, pages = {877--881}, year = {1992}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Evidence based on thermal stability and enzyme inhibition data suggests that the sulfoxidation of the drug toltrazuril by rat liver microsomes is catalyzed by different cytochromes P-450. Pretreatment of rats by different inducers--phenobarbital, 3-methylcholanthrene, dexamethasone, and triacetyloleandomycin--results in a 2.1-, 2.6-, 2.9-, and 1.8-fold increase, respectively, in the rate of sulfoxidation. The highest increase (8.4-fold) was observed after treatment of microsomes from triacetyloleandomycin-treated animals by potassium ferricyanide. Castration and aging also modify the sulfoxidase activity. The relative rate of formation of the two toltrazuril enantiomers [(A)- and (B)-sulfoxides] depends on the source of the microsomes, suggesting that different cytochromes P-450 have different stereoselectivities.}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/20/6/877}, eprint = {https://dmd.aspetjournals.org/content/20/6/877.full.pdf}, journal = {Drug Metabolism and Disposition} }