RT Journal Article
SR Electronic
T1 THE ACETYLATOR PHENOTYPE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 71
OP 73
VO 2
IS 1
A1 MARCUS M. REIDENBERG
A1 JOHN H. MARTIN
YR 1974
UL http://dmd.aspetjournals.org/content/2/1/71.abstract
AB Because patients developing systemic lupus erythematosus after taking hydralazine have been shown to be genetic slow acetylators, we determined the acetylator phenotype of 14 patients with spontaneous systemic lupus erythematosus. Ten were unequivocally slow acetylators, one was probably slow, one was indeterminate by our method of phenotyping using dapsone, and two were rapid acetylators. This predominance of slow acetylators is different from the expected even distribution of slow and rapid acetylators in the population. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics