@article {HANDY214, author = {R. W. HANDY and K. H. PALMER and M. E. WALL and C. PIANTADOSI}, title = {THE METABOLISM OF ANTIFERTILITY STEROIDS}, volume = {2}, number = {3}, pages = {214--220}, year = {1974}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The in vitro metabolism of chlormadinone acetate (I) has been investigated using human, rabbit, and male rat liver preparations, and the major biotransformation products have been isolated and characterized. The metabolic pathway followed by this synthetic progestin was influenced by the microsomal stimulating property of phenobarbital. Incubations carried out with phenobarbital-stimulated rabbit and male rat livers gave as the major metabolite. 2α-hydroxychlormadinone acetate (III). Incubations carried out with unstimulated human and male rat liver. on the other hand, gave as the major metabolite. 17α-acetoxy-6-chloro-3β-hydroxypregna-4,6-diene-20-one (II). Copyright {\textcopyright} 1974 by The American Society for Pharmacology and Experimental Therapeutics}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/2/3/214}, eprint = {https://dmd.aspetjournals.org/content/2/3/214.full.pdf}, journal = {Drug Metabolism and Disposition} }