PT  - JOURNAL ARTICLE
AU  - R. W. HANDY
AU  - K. H. PALMER
AU  - M. E. WALL
AU  - C. PIANTADOSI
TI  - THE METABOLISM OF ANTIFERTILITY STEROIDS
DP  - 1974 May 01
TA  - Drug Metabolism and Disposition
PG  - 214--220
VI  - 2
IP  - 3
4099  - http://dmd.aspetjournals.org/content/2/3/214.short
4100  - http://dmd.aspetjournals.org/content/2/3/214.full
SO  - Drug Metab Dispos1974 May 01; 2
AB  - The in vitro metabolism of chlormadinone acetate (I) has been investigated using human, rabbit, and male rat liver preparations, and the major biotransformation products have been isolated and characterized. The metabolic pathway followed by this synthetic progestin was influenced by the microsomal stimulating property of phenobarbital. Incubations carried out with phenobarbital-stimulated rabbit and male rat livers gave as the major metabolite. 2α-hydroxychlormadinone acetate (III). Incubations carried out with unstimulated human and male rat liver. on the other hand, gave as the major metabolite. 17α-acetoxy-6-chloro-3β-hydroxypregna-4,6-diene-20-one (II). Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics