PT  - JOURNAL ARTICLE
AU  - N Chouini-Lalanne
AU  - M C Malet-Martino
AU  - V Gilard
AU  - J C Ader
AU  - R Martino
TI  - Structural determination of a glucuronide conjugate of flucytosine in humans.
DP  - 1995 Aug 01
TA  - Drug Metabolism and Disposition
PG  - 813--817
VI  - 23
IP  - 8
4099  - http://dmd.aspetjournals.org/content/23/8/813.short
4100  - http://dmd.aspetjournals.org/content/23/8/813.full
SO  - Drug Metab Dispos1995 Aug 01; 23
AB  - The structure of a glucuronide metabolite of flucytosine (FC; 5-fluorocytosine), found in the urine of all patients treated with this antifungal drug, was determined. This compound is the O2-beta-glucuronide of FC. Its structure was established after isolation from urine and by comparing its spectroscopic characteristics with those of three FC glucuronides previously synthesized. This study is the first report of the identification of a glucuronide of a fluoropyrimidine drug in humans.