RT Journal Article
SR Electronic
T1 Structural determination of a glucuronide conjugate of flucytosine in humans.
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 813
OP 817
VO 23
IS 8
A1 N Chouini-Lalanne
A1 M C Malet-Martino
A1 V Gilard
A1 J C Ader
A1 R Martino
YR 1995
UL http://dmd.aspetjournals.org/content/23/8/813.abstract
AB The structure of a glucuronide metabolite of flucytosine (FC; 5-fluorocytosine), found in the urine of all patients treated with this antifungal drug, was determined. This compound is the O2-beta-glucuronide of FC. Its structure was established after isolation from urine and by comparing its spectroscopic characteristics with those of three FC glucuronides previously synthesized. This study is the first report of the identification of a glucuronide of a fluoropyrimidine drug in humans.