RT Journal Article
SR Electronic
T1 THE <em>IN VITRO</em> HYDROLYSIS OF DI-(2-ETHYLHEXYL)
PHTHALATE BY RAT TISSUES
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 341
OP 344
VO 2
IS 4
A1 JAMES E. CARTER
A1 DAVID B. ROLL
A1 ROBERT V. PETERSEN
YR 1974
UL http://dmd.aspetjournals.org/content/2/4/341.abstract
AB The in vitro hydrolysis of di-(2-ethylhexyl) phthalate to mono-(2-ethylhexyl) phthalate and 2-ethylhexanol is reported. The metabolites have been identified by gas chromatography with supporting experiments employing 14C- and tritium-labeled substrate. The monoester, methylated to form methyl (2-ethylhexyl) phthalate, and 2-ethylhexanol were detected. An esterase or esterases present in rat liver, lung, and kidney appear(s) responsible for the hydrolysis. Subcellular fractionation of the liver indicates that hydrolysis takes place in mitochondria and microsomes but not in cytosol. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics