TY - JOUR T1 - BILIARY EXCRETION AND ENTEROHEPATIC RECIRCULATION OF METHAQUALONE IN THE RAT JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 365 LP - 369 VL - 2 IS - 4 AU - ANDREW POLK AU - ALLYN F. DELONG AU - ROBERT D. SMYTH AU - TIHAMER HERCZEG AU - BERNARD J. BURNS AU - LEWIS J. KLUNK, JR. AU - NELSON H. REAVEY-CANTWELL Y1 - 1974/07/01 UR - http://dmd.aspetjournals.org/content/2/4/365.abstract N2 - Biliary excretion of methaqualone metabolites was demonstrated after oral administration of 2-14C-methaqualone to bile-cannulated rats. Over 5- and 24-hr collection periods, 29 and 77% of the 14C-methaqualone dose appeared in the bile, respectively. Enterohepatic recirculation of the bile metabolites was demonstrated after intraduodenal administration of the bile-derived metabolites to bile-cannulated rats; 18 and 52% of the 14C metabolite dose appeared in the bile at the 5- and 24-hr collection periods. After the intraduodenal administration of the bile-derived metabolites to noncannulated rats, 21 and 37% appeared in the urine at the 24- and 72-hr collection periods. Elucidation of the structure of the biliary metabolites showed that 95% appeared as the O-glucuronide conjugate of 2-methyl-3-(2'-hydroxymethylphenyl)-4(3H)-quinazolinone metabolite and the remaining 5% consisted of two unidentified metabolites. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics ER -