PT - JOURNAL ARTICLE AU - T. INABA AU - E. TSUTSUMI AU - W. A. MAHON AU - W. KALOW TI - BILIARY EXCRETION OF DIAZEPAM IN THE RAT DP - 1974 Sep 01 TA - Drug Metabolism and Disposition PG - 429--432 VI - 2 IP - 5 4099 - http://dmd.aspetjournals.org/content/2/5/429.short 4100 - http://dmd.aspetjournals.org/content/2/5/429.full SO - Drug Metab Dispos1974 Sep 01; 2 AB - Biliary excretion of diazepam and its possible enterohepatic circulation were investigated in the rat. During 4 hr, 77% of the radioactivity injected in the form of [5-14C]diazepam appeared in bile. Radioactivity was eliminated in bile with a half-life of 0.85 hr. Radioactivity in blood in bile-cannulated and control rats declined at essentially the same rate, and blood levels in both groups were not significantly different. This suggested the lack of enteral absorption. Urinary excretion was negligible. No diazepam could be detected in bile; the radioactivity consisted mostly of conjugated metabolites of diazepam. It was concluded that there was virtually no enterohepatic circulation of diazepam in the rat. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics