TY - JOUR T1 - DIBENAMINE IMPAIRMENT OF RAT HEPATIC MICROSOMAL ENZYMES AND ITS RELATION TO HEPATOTOXICITY INDUCED BY CCl<sub>4</sub> AND DIMETHYLNITROSAMINE JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 464 LP - 468 VL - 2 IS - 5 AU - BITTEN STRIPP AU - I. GLENN SIPES AU - HARRIET M. MALING AU - JAMES R. GILLETTE Y1 - 1974/09/01 UR - http://dmd.aspetjournals.org/content/2/5/464.abstract N2 - Pretreatment of rats with dibenamine ·HCl (25 mg/kg sc 48 and 24 hr before death) decreased the activity of cytochrome P-450-dependent enzymes in hepatic microsomes as judged by the in vitro N-demethylation of ethylmorphine and dimethylnitrosamine and covalent binding of 14CCI4 and 14C-dimethylnitrosamine. The decrease in enzymatic activity is probably not due solely to a decrease in the amount of cytochrome P-450. Dibenamine pretreatment may protect rats from the hepatotoxicity of CCl4 or dimethylnitrosamine by reducing the formation of active metabolites by microsomal enzymes. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics ER -