RT Journal Article
SR Electronic
T1 DIBENAMINE IMPAIRMENT OF RAT HEPATIC MICROSOMAL
ENZYMES AND ITS RELATION TO HEPATOTOXICITY
INDUCED BY CCl<sub>4</sub> AND DIMETHYLNITROSAMINE
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 464
OP 468
VO 2
IS 5
A1 BITTEN STRIPP
A1 I. GLENN SIPES
A1 HARRIET M. MALING
A1 JAMES R. GILLETTE
YR 1974
UL http://dmd.aspetjournals.org/content/2/5/464.abstract
AB Pretreatment of rats with dibenamine ·HCl (25 mg/kg sc 48 and 24 hr before death) decreased the activity of cytochrome P-450-dependent enzymes in hepatic microsomes as judged by the in vitro N-demethylation of ethylmorphine and dimethylnitrosamine and covalent binding of 14CCI4 and 14C-dimethylnitrosamine. The decrease in enzymatic activity is probably not due solely to a decrease in the amount of cytochrome P-450. Dibenamine pretreatment may protect rats from the hepatotoxicity of CCl4 or dimethylnitrosamine by reducing the formation of active metabolites by microsomal enzymes. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics