PT  - JOURNAL ARTICLE
AU  - ARTHUR K. CHO
AU  - GERALD T. MIWA
TI  - THE ROLE OF IONIZATION IN THE N-DEMETHYLATION OF SOME N,N-DIMETHYLAMINES
DP  - 1974 Sep 01
TA  - Drug Metabolism and Disposition
PG  - 477--483
VI  - 2
IP  - 5
4099  - http://dmd.aspetjournals.org/content/2/5/477.short
4100  - http://dmd.aspetjournals.org/content/2/5/477.full
SO  - Drug Metab Dispos1974 Sep 01; 2
AB  - The effect of pH on the N-demethylation of a series of arylalkylamines by liver microsomes was examined. As anticipated, the observed rate decreased with decreasing pH for those amines that were ionized in the pH range studied, but the rate decrease could not be explained solely in terms of ionization of the base. The results are interpreted in terms of a model in which the rate is dependent on two equilibria, the ionization of the base and its partition between the microsomes and the aqueous incubation media. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics