@article {AURORI566, author = {KEVIN C. AURORI and ELLIOT S. VESELL}, title = {COMPARATIVE STIMULATORY EFFECTS OF FOUR PHENOTHIAZINES ON HEPATIC MICROSOMAL ENZYMES}, volume = {2}, number = {6}, pages = {566--572}, year = {1974}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Four phenothiazine derivatives were compared with respect to the extent that they stimulated hepatic microsomal drug metabolism of mature male rats. Daily oral administration of chlorpromazine (16 mg/kg) for 3 days stimulated ethylmorphine N-demethylase activity to 135\% of control values, Three- and seven-day pretreatment with promazine, thioridazine, or triflupromazine, and 7-day pretreatment with chlorpromazine stimulated ethylmorphine N-demethylase activity less than observed for 3-day chlorpromazine pretreatment. Administration of chlorpromazine (32 mg/kg) or of promazine (64 mg/kg) for 3 days stimulated both aniline hydroxylase activity and cytochrome P-450 content to levels exceeding 150\% of control values. After 7 days of chlorpromazine or promazine administration, aniline hydroxylase activity declined, whereas cytochrome P-450 content was maintained or increased. After 7 days of pretreatment with thioridazine or triflupromazine, aniline hydroxylase activity and cytochrome P-450 content were weakly stimulated. Copyright {\textcopyright} 1974 by The American Society for Pharmacology and Experimental Therapeutics}, issn = {0090-9556}, URL = {https://dmd.aspetjournals.org/content/2/6/566}, eprint = {https://dmd.aspetjournals.org/content/2/6/566.full.pdf}, journal = {Drug Metabolism and Disposition} }