PT - JOURNAL ARTICLE AU - KEVIN C. AURORI AU - ELLIOT S. VESELL TI - COMPARATIVE STIMULATORY EFFECTS OF FOUR PHENOTHIAZINES ON HEPATIC MICROSOMAL ENZYMES DP - 1974 Nov 01 TA - Drug Metabolism and Disposition PG - 566--572 VI - 2 IP - 6 4099 - http://dmd.aspetjournals.org/content/2/6/566.short 4100 - http://dmd.aspetjournals.org/content/2/6/566.full SO - Drug Metab Dispos1974 Nov 01; 2 AB - Four phenothiazine derivatives were compared with respect to the extent that they stimulated hepatic microsomal drug metabolism of mature male rats. Daily oral administration of chlorpromazine (16 mg/kg) for 3 days stimulated ethylmorphine N-demethylase activity to 135% of control values, Three- and seven-day pretreatment with promazine, thioridazine, or triflupromazine, and 7-day pretreatment with chlorpromazine stimulated ethylmorphine N-demethylase activity less than observed for 3-day chlorpromazine pretreatment. Administration of chlorpromazine (32 mg/kg) or of promazine (64 mg/kg) for 3 days stimulated both aniline hydroxylase activity and cytochrome P-450 content to levels exceeding 150% of control values. After 7 days of chlorpromazine or promazine administration, aniline hydroxylase activity declined, whereas cytochrome P-450 content was maintained or increased. After 7 days of pretreatment with thioridazine or triflupromazine, aniline hydroxylase activity and cytochrome P-450 content were weakly stimulated. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics