RT Journal Article
SR Electronic
T1 COMPARATIVE STIMULATORY EFFECTS OF FOUR PHENOTHIAZINES ON HEPATIC MICROSOMAL ENZYMES
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 566
OP 572
VO 2
IS 6
A1 KEVIN C. AURORI
A1 ELLIOT S. VESELL
YR 1974
UL http://dmd.aspetjournals.org/content/2/6/566.abstract
AB Four phenothiazine derivatives were compared with respect to the extent that they stimulated hepatic microsomal drug metabolism of mature male rats. Daily oral administration of chlorpromazine (16 mg/kg) for 3 days stimulated ethylmorphine N-demethylase activity to 135% of control values, Three- and seven-day pretreatment with promazine, thioridazine, or triflupromazine, and 7-day pretreatment with chlorpromazine stimulated ethylmorphine N-demethylase activity less than observed for 3-day chlorpromazine pretreatment. Administration of chlorpromazine (32 mg/kg) or of promazine (64 mg/kg) for 3 days stimulated both aniline hydroxylase activity and cytochrome P-450 content to levels exceeding 150% of control values. After 7 days of chlorpromazine or promazine administration, aniline hydroxylase activity declined, whereas cytochrome P-450 content was maintained or increased. After 7 days of pretreatment with thioridazine or triflupromazine, aniline hydroxylase activity and cytochrome P-450 content were weakly stimulated. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics