TY - JOUR T1 - FETAL HEPATIC DRUG METABOLISM IN THE NONHUMAN PRIMATE, <em>MACACA ARCTOIDES</em> JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 539 LP - 544 VL - 2 IS - 6 AU - BARRY H. DVORCHIK AU - VINCENT G. STENGER AU - STEVEN L. QUATTROPANI Y1 - 1974/11/01 UR - http://dmd.aspetjournals.org/content/2/6/539.abstract N2 - The metabolism of ethylmorphine, cytochrome P-450 content, and NADPH-cytochrome c reductase activity were measured in liver homogenates from fetal stumptail monkeys (Macaca arctoides) and from human fetuses (12-16 weeks of gestation). At all gestational ages studied, in both species, the rates of ethylmorphine N-demethylation were similar. NADPH-cytochrome c reductase activity and cytochrome P-450 content increased during gestation. These studies indicate that the fetal stumptail monkey may be a good animal model for the study of fetal hepatic drug metabolism and its significance to the developing fetus. Copyright © 1974 by The American Society for Pharmacology and Experimental Therapeutics ER -