%0 Journal Article %A Sandra K. Kirkman %A Mei-Yi Zhang %A Peter M. Horwatt %A JoAnn Scatina %T Isolation and Identification of Bromfenac Glucoside From Rat Bile %D 1998 %J Drug Metabolism and Disposition %P 720-723 %V 26 %N 7 %X Bromfenac (Duract®), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside. The American Society for Pharmacology and Experimental Therapeutics %U https://dmd.aspetjournals.org/content/dmd/26/7/720.full.pdf