RT Journal Article
SR Electronic
T1 Isolation and Identification of Bromfenac Glucoside From Rat Bile
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 720
OP 723
VO 26
IS 7
A1 Sandra K. Kirkman
A1 Mei-Yi Zhang
A1 Peter M. Horwatt
A1 JoAnn Scatina
YR 1998
UL http://dmd.aspetjournals.org/content/26/7/720.abstract
AB Bromfenac (Duract®), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside. The American Society for Pharmacology and Experimental Therapeutics