RT Journal Article
SR Electronic
T1 Novel Metabolic Pathway of Estrone and 17β-Estradiol Catalyzed by Cytochrome P-450
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 110
OP 112
VO 28
IS 2
A1 Tomoyuki Ohe
A1 Masaaki Hirobe
A1 Tadahiko Mashino
YR 2000
UL http://dmd.aspetjournals.org/content/28/2/110.abstract
AB We have already reported that the quinol formation from some para-alkylphenols, which is a novel metabolic pathway catalyzed by cytochrome P-450, occurs in a rat liver microsomal system (Ohe et al., 1997). In the present study, we investigated whether estrone and 17β-estadiol, each of which contains ap-alkylphenol moiety, are also oxidized into the corresponding quinols by cytochrome P-450. Six recombinant human cytochrome P-450 enzymes, CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2E1, and CYP3A4, were tested. The results show that estrone and 17β-estadiol were converted into the corresponding quinols by CYP1A1, CYP2B6, and CYP2E1. The American Society for Pharmacology and Experimental Therapeutics