TY - JOUR T1 - Interethnic Variability in Human Drug Responses JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 606 LP - 610 VL - 29 IS - 4 AU - D. A. P. Evans AU - H. L. McLeod AU - S. Pritchard AU - M. Tariq AU - A. Mobarek Y1 - 2001/04/01 UR - http://dmd.aspetjournals.org/content/29/4/606.abstract N2 - The scientific study of interethnic differences in responses to drugs has been extant for 80 years. Many of these differences have been described at the phenotypic level, and some have been explained by genetic factors. However, it is frequently difficult to disentangle accurately the hereditary and environmental influences in phenotypic comparisons. This is where the recent developments in knowledge of the genes responsible for drug receptors are starting to make a big impact. The beta 2 adrenoceptor is described; it has three genetic polymorphisms. The different genotypes influence responses to agonists such as albuterol (Salbutamol). New gene frequency data including those for Saudi Arabians, Indians, and Africans are shown. The expanding body of knowledge about genetic (and interethnic) variability in drug receptors is likely to be important in clinical medicine. The American Society for Pharmacology and Experimental Therapeutics ER -