PT  - JOURNAL ARTICLE
AU  - Edward T. Morgan
TI  - Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?
DP  - 2001 Mar 01
TA  - Drug Metabolism and Disposition
PG  - 207--212
VI  - 29
IP  - 3
4099  - http://dmd.aspetjournals.org/content/29/3/207.short
4100  - http://dmd.aspetjournals.org/content/29/3/207.full
SO  - Drug Metab Dispos2001 Mar 01; 29
AB  - Expression and activities of cytochrome P450 enzymes are down-regulated in the liver during the host response to inflammation or infection, leading to alterations in drug clearance and toxin activation. This review focuses on recent studies on the mechanisms of this down-regulation, as well as the cytokines and cell types involved. Possible reasons for cytochrome P450 down-regulation are discussed. The American Society for Pharmacology and Experimental Therapeutics