RT Journal Article
SR Electronic
T1 Application of Directly Coupled High Performance Liquid Chromatography-NMR-Mass Spectometry and <sup>1</sup>H NMR Spectroscopic Studies to the Investigation of 2,3-Benzofuran Metabolism in  Sprague-Dawley Rats
JF Drug Metabolism and Disposition
JO Drug Metab Dispos
FD American Society for Pharmacology and Experimental Therapeutics
SP 1357
OP 1363
DO 10.1124/dmd.30.12.1357
VO 30
IS 12
A1 Connelly, John C.
A1 Connor, Susan C.
A1 Monte, Soria
A1 Bailey, Nigel J.C.
A1 Borgeaud, Nathan
A1 Holmes, Elaine
A1 Troke, Jeff
A1 Nicholson, Jeremy K.
A1 Gavaghan, Claire L.
YR 2002
UL http://dmd.aspetjournals.org/content/30/12/1357.abstract
AB The urinary excretion of metabolites of 2,3-benzofuran was studied in Sprague-Dawley rats (n = 5) given a single dose of 150 mg/kg i.p. Urine samples were collected at defined intervals up to 7 days postdose and analyzed using 1H NMR and directly coupled high performance liquid chromatography (HPLC)-NMR, HPLC-(mass spectrometry) MS and HPLC-MS-NMR methods. The principal metabolites were determined to be 2-hydroxyphenylacetic acid and 2-(2-hydroxyethyl)phenyl hydrogen sulfate, representing 24.3 ± 6.0% and 19.6 ± 6.4% of the dose, respectively. This indicates that metabolism of benzofuran to the polar species excreted in urine involves cleavage of the furan ring. The American Society for Pharmacology and Experimental Therapeutics