PT  - JOURNAL ARTICLE
AU  - Kouichi Minato
AU  - Naoyuki Koizumi
AU  - Seijirou Honma
AU  - Kunio Tsukamoto
AU  - Satoshi Iwamura
TI  - Pharmacokinetics and Biliary Excretion of Osaterone Acetate, a New Steroidal Antiandrogen, in Dogs
AID  - 10.1124/dmd.30.2.167
DP  - 2002 Feb 01
TA  - Drug Metabolism and Disposition
PG  - 167--172
VI  - 30
IP  - 2
4099  - http://dmd.aspetjournals.org/content/30/2/167.short
4100  - http://dmd.aspetjournals.org/content/30/2/167.full
SO  - Drug Metab Dispos2002 Feb 01; 30
AB  - The pharmacokinetics and biliary excretion of osaterone acetate (17α-acetoxy-6-chloro-2-oxa-4,6-pregnadiene-3,20-dione; OA), a new steroidal antiandrogen, were investigated in intact dogs and biliary fistula dogs after bolus intravenous administration of14C-labeled drug. In intact dogs, OA exhibited a biexponential disposition with a very long half-life of 197.9 ± 109.9 h. OA accounted for almost all the plasma radioactivity. The major route of excretion was in feces via the bile. One-third of the radioactivity in the bile was due to OA. The major biliary metabolite was identified as a glucuronide of 17α-acetoxy-6-chloro-21-hydroxy-2-oxa-4,6-pregnadiene-3,20-dione. A significant amount of biliary recycling occurs in dogs. The American Society for Pharmacology and Experimental Therapeutics