RT Journal Article SR Electronic T1 OXISURAN METABOLISM IN THE MONKEY JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 10 OP 14 VO 3 IS 1 A1 MALCOLM C. CREW A1 LORELEI MITCHELL A1 FELIX DE LA IGLESIA A1 FREDERICK J. DI CARLO YR 1975 UL http://dmd.aspetjournals.org/content/3/1/10.abstract AB Oxisuran metabolism was studied in the Rhesus monkey in order to assess the suitability of this species as an immunological model for man. The biotransformation pathways observed in the monkey are the same as those seen in rats and dogs. These pathways include the oxidation of oxisuran to a sulfone not found in human plasma or urine. Nevertheless, the monkey may merit immunological evaluation because the half-lives of biotransformation and elimination, although shorter than those exhibited by man, are greater than those in dogs and rats. Copyright © 1975 by The American Society for Pharmacology and Experimental Therapeutics